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In some embodiments, the CpG-Ab immunoconjugate is administered to a subject in need thereof in an amount that is not effective for the antibody portion of the CpG-Ab immunoconjugate to induce antibody-dependent cell-mediated cytotoxicity in the subject

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Performed the experiments: JM NM AMB AG NdlC

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In MS, B lymphocytes exhibit a proinflammatory profile that drives cortical pathology and contributes to neurological dysfunction (54)
