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Both tumor and stromal cells release exosomes that carry specific addresses and are selectively internalized by recipient cells to modulate the TME locally or travel through the circulation to other organs [138]

This switch leads to increased Gln utilization by tumor cells and promotes tumor proliferation and metastasis

By utilizing various platforms such as nanomaterials, micelles, and nanoparticles, these delivery systems enhance the controlled release of icariin and icaritin, promote apoptosis, and increase cytotoxicity in a range of cancers

Biering, V

It also supports the chemotaxis (movement) and phagocytosis (pathogen-engulfing ability) of neutrophils and macrophages, ensuring that innate immune cells can effectively navigate to sites of infection