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In the menstrual and early follicular phases, endometrial breakdown and tissue shedding are associated with local innate immune activation and a transient pro-inflammatory profile, characterized by elevated neutrophil infiltration and increased pro-inflammatory cytokines like interleukin 6 (IL-6), IL-8 and IL-1 [75,76]

pylori is a gram-negative, spiral, and microaerophilic bacterium that was discovered by Australian scientists Warren and Marshall in 1982 (Marshall and Warren, 1984)

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Writing original draft: LEM