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Oncolytic viruses: challenges and considerations in an evolving clinical landscape

T., Saeed A., Murtaza B

Chaube, S

1 When IGF-1 binds to IGF-1R, the tyrosine kinase activates the phosphoinositide 3-kinase (PI3K)-AKT pathway and many integral proteins involved in cellular metabolism, apoptosis, cell adhesion, and angiogenesis are regulated within this pathway

Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial
