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46 In a similar vein, the permeability of dissolved gases, including oxygen 47,48 and carbon dioxide, 49 is decreased by the presence of cholesterol

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Pain Processing Mechanisms Central Sensitization (via mGlu2 receptor upregulation)[4][5] Neuroinflammation (modulates glial activation)[12][13] Mitochondrial Dysfunction (enhances ATP production, -oxidation)[2][13] Oxidative Stress (direct antioxidant activity)[2][13] Systemic Inflammation limited direct evidence SUMMARY OVERVIEW CLINICAL PEARLS 1

The same limitation applies to generic lip balms and moisturizers marketed as "brightening" or "lightening." Hydration improves the overall appearance of the lip, which can make discoloration less visually prominent, but it does not address the biology of the pigmentation

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