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13 Inflammation mediated by immune cells was enhanced in degenerated IVDs, and degradation products of these cells, such as IL-4, IL-6, IL-12, IFN-, and MMPs, led to a reduction in NP cell number and deterioration of the IVD microenvironment

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Safety, Product Integrity, and the Problem of Unregulated Supply The primary clinical concern is not simply uncertainty regarding biologic effects, but uncertainty regarding product composition, sterility, and manufacturing quality

Elevated serum B12 levels often indicate underlying conditions such as haematological disorders, liver disease, or renal impairment rather than toxicity from supplementation