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Apr 2023;45(2):627-643

However, these combination effects are highly dependent on experimental models and co-administered components: synergistic metabolic improvements have been observed in animal studies (80), whereas some human studies report only modest reductions in liver enzymes without significant changes in broader metabolic parameters (64)

Fat loss is a gradual and structured process

Since it is a central nervous system stimulant so the withdrawal of caffeine from too much intake would create a severe form of anxiety and jittery feelings as well as shaky hands telling stories of extreme withdrawal symptoms

[1] Binienda et al