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Interestingly, many TJ proteins bind to the N-terminal half region of ZO proteins, while the C-terminal region interacts with the actin cytoskeleton and cytoskeleton-associated proteins.37 Among the ZO proteins, the biochemical function and property of ZO-1 have been well examined

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It's important to investigate the cause of deficiency with tests such as anti-intrinsic factor antibodies and to check folate status

43 , 44 This specific function makes hair follicle melanocytes vulnerable to stress-induced graying, differentiating these processes from overall skin dysfunction

However, the VEGF family and its receptors, including VEGFR, have been found to be expressed in about half of the human cancers studied, such as ovarian cancer, melanoma, thyroid cancer, and more [111,112,113,114]