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The second glutamate-permeable channel is the Ca 2+ -independent glutamate-permeable, two-pore domain potassium channel, TREK-1 (Figure 2c), which releases glutamate that targets neuronal mGluRs

N-acetylcysteine (NAC), a precursor to glutathione, enhances intracellular antioxidant defenses and modulates the glutamatergic system, thereby alleviating repetitive behaviors and reducing irritability in children with ASD (Dugosz et al., 2025

High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial

Glutathione Supplementation: Evidence and Provider Considerations Oral glutathione has limited bioavailability due to digestive breakdown, though N-acetylcysteine (NAC), alpha-lipoic acid, and whey protein provide precursors that support endogenous synthesis

Update in Managing PCOS in Women