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The study concluded that B12 deficiency disrupts catecholamine degradation and sympathetic nervous system function, directly contributing to orthostatic intolerance

the 1 mg arm is the lowest measured human pharmacologic activity: Frias Lancet 2018
References 1.Araos R., DAgata E
But adding B12 can help fight fat effectively

But the switch can happen at any dose for any reason, including cost optimization, convenience, or prescriber preference
