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In addition to their catalytic activity, catalases can also function peroxidatively (Figure 3, step 3) to eliminate H 2 O 2 [45, 49]

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Although aprepitant was incapable of antagonizing human MRGPRX2 in vitro , it was found to have an off-target effect on MrgprB2 (a homologous receptor of MRGPRX2) in animal experiments (78, 81)

Intriguingly, previous research demonstrated a functional partnership between the cells glutathione/glutathione disulfide (GSH/GSSG) balance and Atox1s redox state where GSH is able to reduce Atox1 and restore its ability to bind copper (Hatori et al., 2012)

doi: 10.1016/j.cj.2020.06.002