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Efficacy of topical calcineurin inhibitors in psoriasis

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Imbalanced mitochondrial Ca 2+ homeostasis not only exacerbates oxidative stress but also activates the unfolded protein response and pro-inflammatory signaling cascades, establishing a self-amplifying neurodegenerative loop 31

This reduction leads to the production of several compounds, namely dihydrocurcumin, tetrahydrocurcumin, hexahydrocurcumin, hexahydrocurcuminol, ferulic acid, and dihydroferulic acid (Figure 2)

Metabolic effects of a growth hormone fragment (AOD9604) in obese Zucker rats. Obes Res