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Innate and adaptive immune defects in chronic pulmonary aspergillosis
& Bonnin, A
D.McMahonS.Milln-PachecoC.PastorN.et al (2006)
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the piperazinedione scaffold was found to be superior to the hydantoin scaffold, the ethyl and butyl groups were the best among the other tried N-alkyl moieties, and an R configuration at C6 was essential for PDE5 inhibitory activity [241,242]
