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[2] High-dose intramuscular administration creates a tissue depot that releases vitamin D slowly over weeks, potentially enabling a single injection to lift serum 25-hydroxyvitamin D levels into the sufficient range in severe deficiency and to potentially support bone mineralisation, neuromuscular function, and secondary hyperparathyroidism reversal while bypassing the gastrointestinal tract

let the tretinoin do the exfoliation

10.2174/138161208784246199 [DOI] [PMC free article] [PubMed] [Google Scholar] 168.Al-Koussa H, El Mais N, Maalouf H, Abi-Habib R, El-Sibai M

doi: 10.3390/antiox13030375, 35

This review focuses on advances in therapeutic peptide brain delivery as liquid formulations and dry powder inhalers (DPIs), besides highlighting the role of IN-delivered high molecular weight molecules (including peptides) in treating various systemic diseases