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17,49,50 The dosages of medications, mechanism of action, route, and side effects are summarized in Table 4

Petracci M, Mudalal S, Bonfiglio A, Cavani C

Both infectious and noninfectious factors drive disease progression through distinct yet interacting pathological mechanisms

On the other hand, the variance between studies was partially attributed to the treatment duration, accounting for 30.64% of the heterogeneity

Although these acquired functional deficiencies generally produce less severe effects than genetic mutations, they can significantly disrupt metabolic homeostasis in susceptible individuals
