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Metaxas C, Mathis D, Jeger C et al (2017) Early biomarker response and patient preferences to oral and intramuscular Vitamin B12 substitution in primary care: a randomized parallel-group trial

Early treatment can help prevent nerve damage from B12 deficiency

These effects are usually: Mild to moderate in intensity Transient (resolve within days) Responsive to over-the-counter pain relievers Less common with continued use Mild fatigue: Occasional reports of mild fatigue, especially early in treatment: Usually occurs in the first 12 weeks May relate to metabolic adaptation Often resolves with continued use Can be managed with adequate rest and hydration Nausea: Rare reports of mild nausea: Usually mild and transient May relate to injection timing relative to meals Can often be avoided by dosing on an empty stomach Rarely leads to discontinuation Rare or Serious Side Effects Allergic reactions: While rare, allergic reactions to the peptide are possible: Symptoms may include rash, itching, or hives Severe reactions (anaphylaxis) are extremely rare Any sign of an allergic reaction warrants immediate discontinuation Subjects with peptide allergies should be excluded from research Hypoglycemia: Despite AOD9604s lack of direct effects on blood glucose, rare cases of mild hypoglycemia have been reported: Likely related to enhanced fat oxidation and reduced glucose use More common when dosing in a fasted state without later food intake Can be prevented by eating within a reasonable time after injection Subjects with diabetes or glucose-control issues need closer monitoring Safety Compared to Other Compounds The AOD9604 safety profile compares favorably to other fat-loss and metabolic compounds

Genetics may also play a role, as some breeds (like Siamese cats) appear to be more prone to developing the condition

Two powerful components found in the wild soybean include genistein and diadzein