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In addition, VEGFR-2 signaling has been shown to lead to Rho/ROCK activation which then affects downstream enzymes such as focal adhesion kinase (FAK) and transcription factors such as signal transducer and activator of transcription (STAT) (30, 223, 224)

In high-income countries is cigarette smoking a main risk factor for COPD

Halldin CB, Paoli J, Sandberg C, Ericson MB, Wennberg AM
As an essential component of the innate immune repertoire of the CNS, this inflammation is typically mediated by the resident immune cells of the CNS, microglia, in concert with astrocytes, microvascular endothelial cells and peripheral immune cells that can migrate into the CNS
