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The tumor microenvironment (TME) adds another layer of complexity, as shown in cervical cancer cells: MEK inhibition (MEKi) modulates ROS differently across cell lines, with ERK reducing ROS in C33-A cells but increasing it in SiHa and CaSki cells

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Lu, Biochimica et Biophysica Acta - General Subjects 1830, (2013) 31433153

In the Tyr-Cre mouse, Cre is fused to the oestrogen receptor, therefore only when treated with tamoxifen, will Cre result in BrafV600E activation and Pten loss

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