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These molecules not only induce the proliferation and differentiation of mesenchymal fibroblasts, but ultimately promote the development of pulmonary fibrosis ( 7.2 Ferroptosis regulates differentiation of fibroblast During the development of pulmonary fibrosis, fibroblasts undergo aberrant activation and excessive proliferation driven by various cytokines, leading to the accumulation of large amounts of ECM, which in turn causes scarring and stiffening of lung tissue

In the case of anamorelin, the band positions and relative intensities in the ECD spectrum did not change

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Notably, Tagitinin C induces ferroptosis through the PERK/Nrf2/HO-1 signaling pathway