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Williams, B.L., et al

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62 In nose-to-brain delivery systems, nanoemulsions can overcome the limitations of drugs, such as poor bioavailability and water insolubility

More importantly, the tumor-promoting effect of insulin in pancreatic cancer cells and the TME is essential, which makes insulin and its related signal pathway a potential novel target for cancer therapies

Further supporting this hypothesis, when A42 was added to synaptosomes isolated from brains of APOE targeted-replacement mice, the degree of lipid peroxidation assessed by protein-bound HNE and protein oxidation indexed by protein carbonyls and protein-resident 3-nitrotyrosine was greatest in synaptosomes from ApoE4 mice followed by ApoE3 mice and then ApoE2 mice (218), which is the reverse order of the number of Cys residues in the respective apoE proteins in brains of the respective ApoE mice