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Collectively, lactate acts as a metabolic checkpoint that can simultaneously suppress effector T cell functions while fostering immunosuppressive Tregs and, paradoxically, supporting the foundation of long-term immunity via memory CD8 T cells, highlighting a sophisticated and context-dependent immunomodulatory profile

Abstract There is an urgent need for therapeutic interventions for desensitization and antibody-mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific HLA antibodies (DSA)

Death Discov

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Pickart's transcriptomic study (Vasquez-Soltero et al