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Over the last 20 years, however, advances in gene targeting and genome modification in rodent models have allowed the detailed dissection of roles for key molecular mediators and brain regions responsible for this control in vivo to emerge

Consistency and length: trial results peaked near 26 weeks, not 4
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Unlike apoptosis, necroptosis does not rely on caspase activity, but rather is mediated through the cascade activation of key molecules such as RIPK1, RIPK3, and MLKL, which triggers cell membrane rupture and release of cellular contents, thereby activating the immune system [251]

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