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Mol Clin Neuropathol

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Mandal P.K., Saharan S., Tripathi M., Murari G

Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors

These susceptibility loci do not act in isolation but converge on core biological pathways governing intestinal homeostasis, including: (1) Autophagy impairment: Mutations in key autophagy-related genes (e.g., ATG16L1, IRGM, and MST1) disrupt cellular autophagy, compromise intracellular bacterial clearance, and may perpetuate inflammatory responses (Gabbani et al., 2017