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Herrero-Hernandez, C

Shindou, H

When symptoms occur, they typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders that cause the elevation, rather than the high B12 itself

With regard to the claim that TECVAYLI TM may be a preferred treatment for patients unable to access CAR T-cell therapy, the applicant provided data on the number of patients who received CAR T-cell therapy from studies for CD19 CAR T-cell therapies used for B-cell lymphomas

This hinders the synthesis of acetyl-CoA, obstructs the tricarboxylic acid cycle (TCA), and reduces the ingestion of oxygen.32 Cells deficient in HIF-1 were found to have decreased ATP synthesis in low-oxygen settings, resulting in increased ROS production and the facilitation of programmed cell death