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Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway

Given the experimental efficacy of the antidiabetic and antidyslipidemia action of BBR, most of the 18 completed or terminated clinical trials focused on these properties

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Besides its role in long- and medium-chain fatty acid transport and oxidation, carnitine is essential for regulating the availability of nonesterified CoA within the mitochondrial matrix and serves as a reservoir for excess acetyl groups produced during fatty acid and pyruvate oxidation

We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig