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NF-B p65 pathway inhibition occurs through blocking phosphorylation at Ser536 and preventing nuclear translocation, suppressing transcription of pro-inflammatory genes

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Keywords: glutathione, mitochondria, cholesterol, reactive oxygen species, steatohepatitis, Alzheimer disease INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles