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This concern was further underscored by the SYRCLE RoB assessment, which identified high rates of unclear reporting in selection and performance bias domains (e.g., allocation concealment, randomised housing, and caregiver blinding), highlighting the need for more rigorous and standardised reporting practices in preclinical BBB research

Therefore, the actual transport mechanism, i.e., symport and/or antiport is a still an open question: it can be speculated that OCTN2 may show different transport features according to isoforms and to the tissue in which it is expressed (Pochini et al., 2013)

Both the GAD1 and GAD2 genes are expressed in the brain and GAD2 expression also occurs in the pancreas

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