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The resulting accumulation of 7-ketocholesterol (7-KC), a toxic oxysterol enriched in drusen, contributes to oxidative stress, inflammation, and RPE degeneration in AMD

Notably, an enzyme detoxifying PAP into AMP known as FRY1/SAL1 is localized in chloroplasts (Estavillo et al., 2011), and therefore the transport of PAP into chloroplasts is both logical and essential for the cell

Efficacy and safety of fecal microbiota transplantation for the induction of remission in active ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials

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Lucantoni F, Lindner AU, ODonovan N, Dssmann H, Prehn JHM