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It can also affect other organs, including the skin, joints, and lungs

The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)

The VN may exert therapeutic effects on PD through the MGBA, primarily by regulating brain plasticity, maintaining gut homeostasis, modulating the HPA axis, and exerting anti-neuroinflammatory effects (Table 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] 515.Cong J., Wang Y., Zhang X., Zhang N., Liu L., Soukup K., Michelakos T., Hong T., DeLeo A., Cai L., et al