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At therapeutic doses, healthy livers detoxify NAPQI by phase II conjugation with glutathione (GSH) to form inert mercapturate and cysteine metabolites
[DOI] [PubMed] [Google Scholar] 82.Jin L, Lagoda G, Leite R, Webb RC, Burnett AL

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However, clinical translation is hindered by low oral bioavailability, limited BBB permeability, and inconsistent pharmacokinetics
