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The peptides ability to influence melatonin release has also been documented, providing a mechanistic link between DSIP and circadian rhythm regulation that complements its direct effects on sleep architecture

However, when administered at much lower doses, LDN exhibits unique properties that can modulate the immune system, reduce inflammation, and increase the body's production of endorphins

Gamma-aminobutyric acid, most commonly referred to as GABA , is the major inhibitory neurotransmitter found in the human brain and is responsible for calming the mind under excitatory conditions

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2015 Jan;14(1):43-8