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Curr Opin Ophthalmol 2008 Mar

Fasano 2009)

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Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination In various brain disorders characterized by brain inflammation, including multiple sclerosis (MS), microglial cells and astrocytes are key players in neuroinflammation and can be triggered by agents like interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)

In CMD, irregular muscle fiber morphology, including variability in size, fiber splitting, and centrally located nuclei, is common, alongside impaired muscle regeneration, leading to progressive weakness and atrophy