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Skeletal muscle wasting in cachexia and sarcopenia: Molecular pathophysiology and impact of exercise training

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In a controlled, randomized crossover trial by Cox et al., trained endurance athletes ( n = 39) ingested a ketone ester drink at a dose of 573 mg/kg body weight, corresponding to approximately 500 mg/kg -hydroxybutyrate equivalent, which elevated circulating D-HB concentrations to ~ 3 mM within 3060 min

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L-Carnitine acts as a carrier molecule, escorting fatty acids across the mitochondrial membrane, where they are converted into energy through a series of enzymatic reactions