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The release medium was phosphate-buffered saline, prepared according to pharmacopeial standards and consisting of 0.02% KCl (w/v), 0.02% KH 2 PO 4 (w/v), 0.116% Na 2 HPO 4 (w/v), and 0.8% NaCl (w/v) (adjusted with 10 mM NaOH, pH 7.4) ( The CUR was formulated in a 2% polysorbate 80 aqueous solution, achieving a final concentration of 0.6 mg/mL

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REV.05.24

PMC 9367764

Alterations in spine morphology may not only influence synaptic plasticity and information processing but also have a key role in many neurological diseases