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ORourke and colleagues recently provided evidence supporting such a hypothesis, with their study of -6 polyunsaturated fatty acids and their involvement in lifespan extension

doi: 10.1152/ajpcell.00120.2016 99 LeeD

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However, HSR, which is considered as the function of HSPs in response to thermal stress, is not the only necessary event for maintaining homeostasis under the circumstances, as was previously believed

Notably, endogenous lipophilic radical trapping agents (RTAs), such as coenzyme Q10 and vitamins E and K, can halt the lipid peroxidation chain reaction, thereby functioning as non-enzymatic defense mechanisms against ferroptosis (Fig