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[DOI] [PubMed] [Google Scholar] Romero-Puertas M.C., Corpas F.J., Sandalio L.M., Leterrier M., Rodriguez-Serrano M., Del Rio L.A., Palma J.M

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The alkylation of 4-hydroxythalidomide with tert-butyl bromoacetate to obtain a carboxylic acid derivative in order to facilitate the binding to the amine-terminal linker, for example, was carried out by Lis group in order to synthesize different cereblon-based PROTACs promoting the degradation of the 20S proteasome subunit 5