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Further reports are needed to confirm these findings and elucidate the pathogenesis of AED-induced psychosis
Although brain ROS and RNS are second messengers engaged in intracellular signaling at the normal level, elevated free radical levels have detrimental effects on biological macromolecules that are linked to the pathophysiology of NDDs and the aging process [112,113]
For instance, quercetin has demonstrated potent antioxidant properties (163)
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Based on the analysis of the literature on the mitochondrial Ca 2+ regulation in cyclophilin D (SypD)-deficient mice and neurons, Rizzuto et al
