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The decrease in GSH disrupted the REDOX balance, preventing the consumption of intracellular ROS and lipid peroxides, and contributing to oxidative stress in cells, manifesting as a decrease in antioxidant proteins and the appearance of DNA damage

Feb 2022 17th Frontiers in Immunobiology & Immunopathogenesis Symposium 2022, University of Arizona, USA Williams DEJ , Banka A, Jackson R, King K, Van Doorslaer K Single Cell Sequencing Identifies a Role for Arginine Methylation in HPV Infection Nov 2021 International Papillomavirus Conference 2021, International Papillomavirus Society, Canada, Williams DEJ , King K, Jackson R, Van Doorslaer K Single-cell Transcriptomic Analysis of Primary Cervical Keratinocytes Following HPV18 Infection Identifies Protein Arginine Methyltransferase 1 as a Regulator of HPV Gene Expression Award: Best Talk: Basic Sciences Track Nov 2021 University of Arizona Cancer Center Scientific Retreat 2021, University of Arizona, USA, Williams DEJ , King K, Jackson R, Van Doorslaer K Primary Keratinocyte HPV Infection Model Identifies a Role for Arginine Methylation in Persistent Infection Aug 2021 Cancer Biology: Past Present and Future 2021, University of Arizona, USA, Williams DEJ , King K, Jackson R, Rodriguez A, Van Doorslaer K Single Cell Sequencing Identifies a Role for Arginine Methylation in Persistent HPV Infection Award: 1st Place Poster Award Aug 2021 Cancer Biology: Past Present and Future 2021, University of Arizona, USA, Jackson R, Rajadhyaksha EV, Williams DEJ , King K, Van Doorslaer K Deciphering HPV infection in lab-grown 3D tissues

Symptoms: In RA, joint stiffness, discomfort, and edema are typical

Importantly, many of the pathways susceptible to redox modulation are actively involved in the pathogenesis of ALD, including the NRF2 and AMPK pathways