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It is worth emphasizing that the hypoxia microenvironment induced by the E-P-OS network itself can directly activate the transcription of glycolysis-related genes such as glucose transporter 1 and lactate dehydrogenase A via HIF-1, thereby further enhancing glycolysis and ensuring energy supply for fibroid cells under hypoxic conditions [108]

The symmetry of the funnel plot was further evaluated by Egger's linear regression test [6]

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DOI: 10.18773/austprescr.2015.055

Furthermore, Mohajerani et al
