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Besides diabetes and high blood pressure, the following additional health conditions may also contribute to CKD 1 : Cardiovascular disease Systemic or kidney infections Immune system conditions (eg, lupus) Inflammation of the glomeruli (tiny filters) in the kidneys Inherited kidney disease (eg, polycystic kidney disease) Congenital defects (eg, kidney malformation, urinary tract obstruction) Medications and toxins (eg, prolonged medication, chemical, or street drug exposure) Factors such as those described above and various others can contribute to the decline in kidney function characteristic of CKD

In a subset of patients recovered from COVID-19, long-term dysbiosis correlated with PASC symptoms, especially fatigue, joint pain, diarrhea, headache, depression, and anxiety 246

What pathological process could be responsible for a very slow, multifocal white matter degeneration that seems to track along connected pathways

Given the complexity of digestion, the relative dimensions of the gut, and the time it takes to process meals, organizing and regulating digestion and defense is a task of considerable magnitude: a task worthy of a brain. In fact, vertebrates utilize two brains to regulate the gut: the CNS (brain and spinal cord) and the enteric nervous system (ENS), the system of nerves within the wall of the GI tract

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