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10.1080/15384101.2022.2100682 65 JaglinM.RhimiM.PhilippeC.PonsN.BruneauA.GoustardB.et al (2018)

Exosomes derived from Schwann cells ameliorate peripheral neuropathy in type 2 diabetic mice
Freezing and thawing can cause the peptide to aggregate and lose its structure, potentially rendering it inactive or altering its absorption characteristics

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The hardware (muscle) works, but the software (brain) has deleted the driver