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NFE2L2 NFE2L2 is a master transcription factor that can coordinate the activation of a large number of cell protection genes involved in iron metabolism, oxidative defense and redox signaling during ferroptosis (Fig

Those reactive oxygen species then (1) get in touch with the lens proteinsthe crystallins we just mentionedand, by nature of their reactivity, damage them via protein damaging processes called oxidation, carbonylation, and amino acid crosslinking

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