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NADPH in Cholesterol Synthesis Several enzymes in the pathway of cholesterol synthesis require NADPH for their activities

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Its biosynthesis is a two-step enzymatic cascade, including first a specific -ligation of glutamate and cysteine by -glutamate-cysteine ligase (GCL) and then the formation of peptide bond between this dipeptide and glycine by glutathione synthetase (GS)

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Marcillat O, Zhang Y, Davies KJ

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Unfortunately, many peopleespecially those with digestive issues, restricted diets, or high stressdont absorb enough B12 from food alone

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