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Understanding the slower onset can help you manage expectations and prepare for a different pain relief experience that offers a more sustainable path forward

Kupferschmidt and Lovinger, 2015), interference with vesicle fusion and release machinery (Kupchik et al., 2008, 2011), and activation of presynaptic potassium channels (Anwyl, 1999)

Seek urgent same-day assessment or call 999 for emergency care if experiencing: Severe chest pain Severe shortness of breath Fainting or collapse Acute or rapidly worsening neurological deficits (such as new limb weakness, sudden gait disturbance, or bladder/bowel dysfunction) Persistent or worsening anaemia symptoms despite treatmentincluding breathlessness, chest discomfort, palpitations, or extreme fatigueshould trigger medical review

contributes to the functioning of the nervous system