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We used a human BBB co-culture model improved by cARLA treatment, as described in our paper [40], for the impedance, cellular uptake and permeability experiments
In detail, immature astrocytes express high levels of thrombospondin during the first week of postnatal development, an extracellular matrix protein that plays a critical role in synapse formation in the cerebral cortex (Christopherson et al., 2005)

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Adipex and Suprenza (phentermine) Qsymia (phentermine-topiramate) Contrave (naltrexone-bupropion) Xenical and Alli (orlistat) Imcivree (setmalanotide) Plenity (carboxymethylcellulose hydrogel) Several additional agents are used off-label for weight loss at acceptable risk when prescribed thoughtfully and documented as off-label
