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61 Additionally, when AKG is transformed into 2-hydroxyglutaric acid by isocitrate dehydrogenase 1 and 2 following mutation induction, it inhibits DNA demethylation enzymes and histone methylation enzymes that result in lysine residues (K) 9, 27 DNA methylation and histone methylation

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There was also no significant difference at 4 or 9 months of age (data not shown)

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