l carnitine mechanism of action Role in disease | Nutrition & Metabolism Potential mechanisms of action of

Volume overload from too much fluid disrupts electrolyte balance

Another drug repurposed is metformin (clinically used as an anti-diabetic) which is being used as an AMPK activator, currently in phase II clinical trials for CLL (ClinicalTrials.gov: NCT01750567) (105, 106)

Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation

The increase in MDHAR activity has been reported in stress conditions like salinity, high light, UV radiation, boron toxicity and low temperature (Mittova et al., 2003

Int Rev Cell Mol Biol (2012) 298:229317