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Therefore, the GLP-1 and GIP/GLP-1 receptor agonists in this clinical setting have value in their weight reduction potential and glucose metabolism normalization as well as cardiovascular risk reduction and could even progress to first-line therapy for obstructive sleep apnea [73]

In the nucleus of hepatocyte, the active form of PKA leads to the activation of transcription factor CREB that links the active site of CRE on PGC-1 gene promoter

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DouthwaiteJAJohnsonTSHaylorJLWatsonPEl NahasAM

The results showed that the DSS-Con A group had significantly higher plasma concentration of FITC-dextran compared with the Con A group ( Figure 3A )
