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The heart is the most oxidative tissue in the body and ~5070% of ATP is synthesized through the oxidation of fatty acids [174] with 3040% derived from aerobic glycolysis

Xiao, D., Powolny, A

Less is known about how changes in gliotransmission contribute to the pathology of neurological, neuropsychiatric, or neurodegenerative conditions

Nature 471, 504507

RLS can be primary (no underlying condition) or secondary (due to another condition such as iron deficiency, kidney disease, or diabetes)
