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Nonetheless, recent evidence suggest that there is a fine line between protective and pathogenic astrocyte-mediated functions of BDNF, as astrocytes themselves respond to increased levels of BDNF with the secretion of neurotoxic amounts of nitric oxide (NO), demonstrating a sophisticated feedback loop that prevents excessive BDNF signaling (129)

Luteolin suppressed the increase in p16ink4a-positive cells in bulges, which refers to aging keratinocyte stem cells that gather in the root area of hair follicles, Professor Kato explained

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